Featured Presentation: Historical Perspective on Migraine Treatment*
| Saturday, June 15, 2024 |
| 9:40 AM - 10:00 AM |
| Grand Ballroom 5-9 |
Overview
*Session is not eligible for CME credit*
Details
The history of migraine treatments will be presented with focus on the underlying biological mechanisms. Early development of prophylactic drugs was not based on neurobiological evidence. Thus ,the first drugs were modified ergots and beta blockers were fortuitously discovered when used for arterial hypertension. Valproate was just tried because it was an antiepileptic. Acute treatments were more evidence based. Studies of serotonin stimulated the development of the triptans. Knowledge of regional cerebral blood flow changes suggesting cortical spreading depression led to tonabersat with prophylactic effect in migraine with- but not without aura (not marketed). The invention of a human migraine provocation model showed possibilities in the nitric oxide triggered cascade (not yet exploited) and strongly supported the development of CGRP antagonistic drugs. The same model has suggested many novel targets for drug development in migraine, most notably PACAP(validated) and potassium channels
Speaker
Jes Olesen
Professor Of Neurology
Rigshospitalet Glostrup
Historical Perspective on Migraine Treatment
9:40 AM - 10:00 AM
Dr. Olesen is a professor of neurology at the University of Copenhagen, Denmark and the founder and co-chair of the Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup in Copenhagen, Denmark.
He received his MD and doctorate at the University of Copenhagen and clinical education at associated hospitals and at Queen Square, London and Cornell Medical Center, New York.
He has published 35 books and 700 original scientific articles in peer reviewed journals. He has supervised over 60 dissertations. He is one of the founders and past president of the European Federation of Neurological Societies and of the European Brain Council. He has received several Danish and International awards including The Brain Prize, honorary doctorates and is an honorary member of many societies. He gives one or more invited/named lectureships every year. He has over 100.000 citations and an H-factor of 147.
He has studied almost all aspects of migraine and other headaches. His current focus is on genetics and on animal and human models of migraine.
