6 Pre Course: Advanced Course: Translational Mechanisms of Neuromodulation
Tracks
Thursday, November 16, 2023 |
2:00 PM - 5:00 PM |
Arizona Ballroom Salon A-G |
Details
Speaker
Andy Russo
University of Iowa
Welcome and introduction
2:00 PM - 2:05 PMPresentation Description
We will briefly introduce the topics to be covered in the session.
Stephen Silberstein
Jefferson Headache Center
Welcome and introduction
2:00 PM - 2:05 PM
Stewart Tepper
Vice President
The New England Institute For Neurology And Headache
Overview of the Neuromodulation Devices
2:05 PM - 2:35 PMPresentation Description
Brief overview of the FDA-cleared non-invasive neuromodulation devices for primary headaches.
Catherine Chong
Career Scientist
Mayo Clinic
Understanding Central Pain Mechanisms Through Imaging
2:40 PM - 3:10 PMPresentation Description
Human imaging techniques such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and Magnetoencephalography (MEG) provide crucial insights to our understanding of central pain mechanisms.
This presentation will explore results from imaging data that elucidate the role of the descending pain modulatory system and its dysfunction in chronic pain as well as provide insights into brain activation and connectivity patterns involved in pain perception, pain modulation, and pain sensitization.
Additionally, brain imaging data that explore the neural processes and therapeutic effects underlying neurostimulation techniques for chronic pain will be discussed.
This presentation will explore results from imaging data that elucidate the role of the descending pain modulatory system and its dysfunction in chronic pain as well as provide insights into brain activation and connectivity patterns involved in pain perception, pain modulation, and pain sensitization.
Additionally, brain imaging data that explore the neural processes and therapeutic effects underlying neurostimulation techniques for chronic pain will be discussed.
Peter Goadsby
Professor Emeritus
UCLA
Vagus Nerve Stimulation
3:25 PM - 3:55 PMPresentation Description
Vagus nerve antomy and physiology relevant to head pain will be reviewed. The clinical data for the use of non-invasive vagus nerve stimulation will be presented.
Greg Dussor
University of Texas at Dallas
Descending Modulation and Pain Gating
4:00 PM - 4:30 PMPresentation Description
Descending circuits originating in multiple brain regions and signaling through the periaqueductal grey (PAG) and rostroventromedial medulla (RVM) to the dorsal horn of the spinal cord are critical in the endogenous modulation of pain. The output of these pathways uses multiple neurotransmitter systems to modulate incoming nociceptive signals as they enter the central nervous system and are projected to the brain. These circuits are influenced by opioids through mu-opioid receptors that are expressed throughout these pathways. Endogenous pain control under situations of extreme emotional states is also thought to be mediated by the activity of these circuits. This presentation will review the anatomy of these descending modulatory circuits. Also covered will be data from preclinical studies that have tested the physiology and pharmacology of pain modulatory circuits in rodent models. For example, preclinical studies have shown that activity of intact descending modulatory circuits can regulate the expression of pain through the release of norepinephrine in the spinal cord, which is consistent with the efficacy of drugs for pain that modulate norepinephrine release or reuptake (e.g. clonidine and nortriptyline). Data will also be presented from studies that have examined plasticity in these pathways that may contribute to persistent forms of pain.
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